DelveInsight’s, “Advanced Renal Cell Carcinoma Pipeline Insight, 2023” report provides comprehensive insights about 50+ companies and 60+ pipeline drugs in the Advanced Renal Cell Carcinoma pipeline landscape. It covers the Advanced Renal Cell Carcinoma pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Advanced Renal Cell Carcinoma therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
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Key Takeaways from the Advanced Renal Cell Carcinoma Pipeline Report
For further information, refer to the detailed Advanced Renal Cell Carcinoma Unmet Needs, Advanced Renal Cell Carcinoma Market Drivers, and Advanced Renal Cell Carcinoma Market Barriers, click here for Advanced Renal Cell Carcinoma Ongoing Clinical Trial Analysis
Advanced Renal Cell Carcinoma Overview
Renal Cell Carcinoma (RCC) is the most common type of kidney cancer. This type of cancer develops in the lining of very small tubes, or tubules, inside the kidney. These tubules help to remove waste products from the blood. Stage 4 RCC is the most advanced stage where the disease has spread from the kidneys to one or more distant areas of the body. According to a 2016 study Trusted Source, the outlook for advanced RCC depends largely on where the new tumors are growing in the body. For example, people with RCC that has spread to the pancreas have a higher overall survival rate than those where cancer has spread to the brain, bones, or liver.
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Advanced Renal Cell Carcinoma Emerging Drugs
Belzutifan: Merck Sharp & Dohme
Belzutifan is an inhibitor of hypoxia-inducible factor 2 alpha (HIF-2a). Belzutifan binds to HIF-2a, and in conditions of hypoxia or impairment of VHL protein function, belzutifan inhibits the HIF-2a-HIF-1ß interaction, leading to reduced transcription and expression of HIF-2a target genes. Currently, the drug is being evaluated in the Phase III stage of its development for the treatment of advanced renal cell carcinoma.
IPI-549: Infinity Pharmaceuticals
Eganelisib is a first-in-class, oral, once-daily, immuno-oncology development candidate that selectively inhibits phosphoinositide-3-kinase gamma (PI3K-gamma). Selective PI3K-gamma inhibition represents a unique and potentially transformative approach within immuno-oncology (I/O), and IPI-549 has the potential to be a first-in-class therapy. Preclinical research conducted by Infinity and academic collaborators demonstrates that IPI-549 works by reprogramming key immune suppressive cells (called M2 macrophages or myeloid derived suppressor cells (MDSCs)) within the tumor microenvironment from a pro-tumor function to an anti-tumor function, decreasing immune suppression and increasing immune activation, ultimately leading to the activation and proliferation of T cells that can attack cancer cells. Currently, the drug is being evaluated in the Phase II stage of its development for the treatment of advanced renal cell carcinoma.
JANX008: Janux Therapeutics
JANX008 is an EGFR-TRACTr that is designed to overcome CRS and known on-target EGFR healthy tissue toxicities. Epidermal growth factor receptor (EGFR) is a clinically validated target highly expressed on many solid tumors that are being underserved by current therapies. JANX008 targets EGFR for the treatment of multiple solid cancers including, but not limited to, colorectal cancer (CRC), squamous cell carcinoma of the head and neck (SCCHN), non-small cell lung cancer (NSCLC), and renal cell carcinoma (RCC). Currently, the drug is being evaluated in the Phase I stage of its development for the treatment of advanced renal cell carcinoma.
Dive deep into rich insights for drugs for Advanced Renal Cell Carcinoma Market Drivers and Advanced Renal Cell Carcinoma Market Barriers, click here @ Advanced Renal Cell Carcinoma Unmet Needs and Analyst Views
Advanced Renal Cell Carcinoma Pipeline Therapeutics Assessment
There are approx. 50+ key companies which are developing the therapies for Advanced Renal Cell Carcinoma. The companies which have their Advanced Renal Cell Carcinoma drug candidates in the most advanced stage, i.e. phase III include, Merck Sharp & Dohme.
Scope of the Advanced Renal Cell Carcinoma Pipeline Report
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